I am not believing that this new label diligently reflects the belongings in new report

Authors’ impulse

What’s the way for defining quick-changing and sluggish-growing protein-programming genes? If your method is just “Explore Ka”, I’d believe men and women have complete you to definitely ahead of.

Authors’ response

We have changed the fresh name so you’re able to “Nonsynonymous replacing speed (Ka) is a fairly consistent parameter for identifying prompt-developing and slow-growing proteins-programming genes”. I have seemed brand new related books carefully and then have not located publications which have done including comprehensive feedback to the actions.

Records

Lander Parece, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle Yards, FitzHugh W, et al: Initially sequencing and you may studies of one’s person genome. Character. 2001, 409: 860-921. 7062.

Demuth JP, De- Bie T, Stajich JE, Cristianini Letter, Hahn MW: The latest advancement out-of mammalian gene household. PLoS You to. 2006, 1: e85-/diary.pone.0000085.

Williamson SH, Hubisz MJ, Clark AG, Payseur BA, Bustamante Computer game, Nielsen R: Localizing present adaptive development in the human genome. PLoS Genet. 2007, 3: e90-/journal.pgen.0030090.

Bustamante Computer game, Fledel-Alon A beneficial, Williamson S, Nielsen R, Hubisz MT, Glanowski S, Tanenbaum DM, White TJ, Sninsky JJ, Hernandez RD, Civello D, Adams MD, Cargill Yards, Clark AG: Pure choice for the healthy protein-programming family genes in the human genome. Character. 2005, 437: 1153-1157. /nature04240.

Nielsen R, Bustamante C, Clark AG, Glanowski S, Sackton TB, Hubisz MJ, Fledel-Alon A beneficial, Tanenbaum DM, Civello D, White TJ, J Sninsky J, Adams MD, Cargill Yards: A scan to have undoubtedly selected genetics about genomes out of individuals and you will chimpanzees. PLoS Biol. 2005, 3: e170-/log.pbio.0030170.

Kosiol C, Vinar T, da Fonseca RR, Hubisz MJ, Bustamante Video game, Nielsen R, Siepel Good: Activities out-of confident selection in the half dozen Mammalian genomes. PLoS Genet. 2008, 4: e1000144-/record.pgen.1000144.

Clark AG, Glanowski S, Nielsen R, Thomas PD, Kejariwal A great, Todd MA, Tanenbaum DM, Civello D, Lu F, Murphy B, Ferriera S, Wang G, Zheng X, White TJ, Sninsky JJ, Adams MD, Cargill M: Inferring nonneutral development out of person-chimp-mouse orthologous gene trios. Technology. 2003, 302: 1960-1963. /science.1088821.

Locke DP, Hillier LW, Warren W.c., Worley KC, Nazareth LV, Muzny DM, Yang SP, Wang Z, Chinwalla At the, Minx P, mais aussi al: Relative and market data away from orang-utan genomes. Nature. 2011, 469: 529-533. /nature09687.

Gibbs RA, Rogers J, Katze Mg, Bumgarner R, Weinstock GM, Mardis Er, Remington KA, Strausberg RL, Venter JC, Wilson RK, et al: Evolutionary and biomedical understanding in the rhesus macaque genome. Science. 2007, 316: 222-234. /science.1139247.

Wade CM, Giulotto Elizabeth, Sigurdsson S, Zoli Meters, Gnerre S, Imsland F, Lear TL, Adelson DL, Bailey Age, Bellone RR, mais aussi al: Genome succession, relative data, and population genes of the domestic horse. Research. 2009, 326: 865-867. /technology.1178158.

Lindblad-Toh K, Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, Kamal M, Fasten M, Chang JL, Kulbokas EJ, Zody MC, ainsi que al: Genome succession, comparative analysis and haplotype framework of your own home-based puppy. Character. 2005 https://www.datingranking.net/eharmony-vs-christian-mingle/, 438: 803-819. /nature04338.

Elsik CG, Tellam RL, Worley KC, Gibbs RA, Muzny DM, Weinstock GM, Adelson DL, Eichler EE, Elnitski L, Guigo Roentgen, et al: The brand new genome series from taurine cows: a windows so you can ruminant biology and you may progression. Research. 2009, 324: 522-528. /science.1169588.

Waterston RH, Lindblad-Toh K, Birney Age, Rogers J, Abril JF, Agarwal P, Agarwala Roentgen, Ainscough R, Alexandersson Yards, A keen P, ainsi que al: Very first sequencing and relative data of the mouse genome. Character. 2002, 420: 520-562. /nature01262.

Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, ainsi que al: Genome succession of your own Brownish Norway rodent efficiency expertise on mammalian development. Nature. 2004, 428: 493-521. /nature02426.

Mikkelsen TS, Wakefield MJ, Aken B, Amemiya CT, Chang JL, Duke S, Garber Yards, Gentles AJ, Goodstadt L, Heger An excellent, et al: Genome of one’s marsupial Monodelphis domestica reveals for the, 447: 167-177. /nature05805.